Publications

2022

Heckenbach, I., Mkrtchyan, G.V., Ezra, M.B., Bakula, D., Madsen, J.S., Nielsen, M.H., Oró, D. Osborne, B., Covarrubias, A.J., Idda, M.L., Gorospe, M., Mortensen, L., Verdin, E., Westendorp, R., Scheibye-Knudsen, M. Nuclear morphology is a deep learning biomarker of cellular senescence. Nature Aging 2, 742–755.

2021

Covarrubias, Anthony J., Rosalba Perrone, Alessia Grozio, and Eric Verdin. “NAD + Metabolism and Its Roles in Cellular Processes during Ageing.” Nature Reviews Molecular Cell Biology 22 (2): 119–41.

2020

Covarrubias, A.J., Abhijit Kale, Rosalba Perrone, Jose Alberto Lopez-Dominguez, Angela Oliveira Pisco, Herbert G. Kasler, Mark S. Schmidt, et al. n.d. “Senescent Cells Promote Tissue NAD + Decline during Ageing via the Activation of CD38 + Macrophages.” Nature Metabolism.

2019

Covarrubias, Anthony J., Abhijit Kale, Rosalba Perrone, Jose Alberto Lopez-Dominguez, Angela Oliveira Pisco, Herbert G. Kasler, Mark S. Schmidt, et al. “Aging-Related Inflammation Driven by Cellular Senescence Enhances NAD Consumption via Activation of CD38+ pro-Inflammatory Macrophages.” BioRxiv, 609438.

2017

Newman, John C., Anthony J. Covarrubias, Minghao Zhao, Xinxing Yu, Philipp Gut, Che-Ping Ng, Yu Huang, Saptarsi Haldar, and Eric Verdin. “Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice.” Cell Metabolism 26 (3): 547-557.e8.

2016

Covarrubias, Anthony J, Halil Ibrahim Aksoylar, Jiujiu Yu, Nathaniel W Snyder, Andrew J Worth, Shankar S Iyer, Jiawei Wang, et al. “Akt-MTORC1 Signaling Regulates Acly to Integrate Metabolic Input to Control of Macrophage Activation.” ELife 5: e11612.

Covarrubias, Anthony Joseph. The Role of Nutrient Sensing in Macrophage Polarization. Doctoral dissertation, Harvard University, Graduate School of Arts & Sciences.

2015

Covarrubias, Anthony J., H. Ibrahim Aksoylar, and Tiffany Horng. “Control of Macrophage Metabolism and Activation by MTOR and Akt Signaling.” Seminars in Immunology, Macrophage activation and polarization, 27 (4): 286–96.

2014

Covarrubias, Anthony J., and Tiffany Horng. “IL-6 Strikes a Balance in Metabolic Inflammation.” Cell Metabolism 19 (6): 898–99.

2013

Byles, Vanessa, Anthony J. Covarrubias, Issam Ben-Sahra, Dudley W. Lamming, David M. Sabatini, Brendan D. Manning, and Tiffany Horng. “The TSC-MTOR Pathway Regulates Macrophage Polarization.” Nature Communications 4: 2834.

Covarrubias, Anthony, Vanessa Byles, and Tiffany Horng. “ROS Sets the Stage for Macrophage Differentiation.” Cell Research 23 (8): 984–85.

2010

Chin, Arnold I., Andrea K. Miyahira, Anthony Covarrubias, Juli Teague, Beichu Guo, Paul W. Dempsey, and Genhong Cheng. “Toll-like Receptor 3–Mediated Suppression of TRAMP Prostate Cancer Shows the Critical Role of Type I Interferons in Tumor Immune Surveillance.” Cancer Research 70 (7): 2595–2603.